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Selected Readings in
Vision and Graphics
edited by Luc Van Gool, Gábor Székely, Markus Gross, Bernt Schiele
Robert H. P. McGregor
Enhancing Medical Images with High
Quality Blood Flow Information
2010. XVI, 172 pages. EUR 64,00.
Cardiovascular diseases are the leading cause of mortality in developed countries. Their pathogenesis and development are complex and multifactorial, depending on a variety of biochemical and biomechanical factors and are still not completely understood. Local haemodynamics are increasingly recognised as a key component to the disease initiation process and yet there is a lack of efficient tools for imaging such processes in-vivo, leading to a gap in diagnostic capabilities and limited research possibilities. The objective of this thesis is to investigate the enhancement of medical images with high-quality blood flow information and to propose a novel, clinically applicable approach. In an initial step, several methodological improvements to the current computational blood flow simulation pipeline are presented focusing principally on surface mesh generation, computational flow simulation using FEM and FVM and fluid-structure interaction. Research is further concentrated on creating an original flow measurement enhancement method, using a database of precomputed simulations and principal component analysis to interpolate a patient-specific flow field based on data acquired using medical imaging. The experiments show this new approach to be highly promising and demonstrate it to be a fast, clinically-feasible alternative to fully-blown flow simulation.
Robert McGregor obtained his M.Sc. (Dipl.-Ing.) degree in Mechanical Engineering from the ETH Zurich in 2004. He performed his master thesis in collaboration with Zimmer Orthopedics in the field of experimental orthopedic imaging and then continued working for them in the same field. From 2006 until 2010 he worked as a research assistant and PhD student in the field of medical imaging at the Computer Vision Laboratory. In 2010 he was awarded a PhD degree (Dr. Sc. ETH) from the ETH Zurich for his doctoral thesis “Enhancing Medical Images with High Quality Blood Flow Information”.
Keywords: Computational Fluid Dynamics, Magnetic Resonance Imaging, Blood Flow Measurement, Blood Flow Simulation, Mesh Generation, Flow Measurement Enhancement, Biomedical Flow Imaging
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